工作经历

2019/1-至今：中科院青岛生物能源与过程研究所分子微生物工程研究组，研究员

2017/1-2018/12：中科院青岛生物能源与过程研究所分子微生物工程研究组，项目研究员

2013/12-2016/12：中科院青岛生物能源与过程研究所，副研究员

2013/08-2014/08：美国麻省理工学院，化学工程系，访问学者

2008/07-2012/12：中科院青岛生物能源与过程研究所，助理研究员

个人简历

王士安，研究员，博士生导师。2003年本科毕业于陕西师范大学；2008年在中国科学院微生物研究所获得博士学位，同年加入中国科学院青岛生物能源与过程研究所，工作至今；其间，2013年至2014年，赴美国麻省理工学院开展代谢工程研究和学习。聚焦酵母菌合成油脂和蛋白，“因菌制宜与因品制宜”的建立了解脂耶氏酵母、红法夫酵母、酿酒酵母、毕赤酵母研究平台，解析底盘的遗传与代谢调控机理，开发基因编辑、定向进化、高通量筛选等技术，发展高产菌种和发酵工艺。神经酸油脂、虾青素、酵母单细胞蛋白等技术实现转让。在PNAS、Science Advances等期刊发表SCI论文30余篇；申请PCT和发明专利22项，已获中国、美国、日本和欧洲授权12项。承担国家重点研发计划项目和省部级项目多项。担任The Global Energy Association评审委员会委员等。

代表论著

1. Ruilin Huang, Jiurong Wang, Ruirui Ding, Yu Liu, Juanjuan Su, Zhihang Chen, Yong Fan, Fuli Li, Linqi Wang, Xiao Liu and Shi’an Wang*. A conserved E3 ubiquitin ligase rewires carotenoid, sterol, and lipid metabolism in Xanthophyllomyces dendrorhous. PNAS, 2026, 123(17):e2530496123

2. Qian Ling^# , Bozhao Li^# , Yuhua Feng, Jing Yang*, Shi’an Wang*, Suping Li*, Cheng Zhang*. Conformation Programmed DNA Computing. Science Advances, 2026, 12(8):eaec8383.

3. Zhihang Chen^#, Jiajun Deng^#, Peijie Han^#, Jiabao Li, Dong Li*, and Shi’an Wang*. Mass production of microbial protein using low-value materials. The Innovation Life, 2026, 4:100200.

4. Juanjuan Su, Shiyou Xing, Wei Qi, Shi’an Wang*. Scaling sustainable aviation fuel from microbial oils: challenges and opportunities. 10 Breakthrough Ideas in Energy for The Next Ten Years (6th Anniversary edition), 2025, 25-33.

5. Shi’an Wang*, Juanjuan Su. Organisms for biofuel production. 10 Breakthrough Ideas in Energy for The Next Ten Years (5th Anniversary edition), 2024, 18-26.

6. Ruirui Ding, Ruilin Huang, Hang Su, Jiawen Li, Fuli Li, Shi’an Wang*. Screening of astaxanthin-overproducing Xanthophyllomyces dendrorhous strains via iterative ARTP mutagenesis and cell sorting by flow cytometry. J Appl Microbiol, 2024, 135(2):lxae020.

7. Hang Su^#, Penghui Shi^#, Zhaoshuang Shen^#, Huimin Meng, Ziyue Meng, Xingfeng Han, Yanna Chen, Weiming Fan, Yun Fa, Chunyu Yang, Fuli Li^*, Shi’an Wang^*. High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by systematic metabolic engineering. Communications Biology, 2023, 6:1125.

8. Qingqing Xu^#, Qingyun Tang^#, Yang Xu, Junjun Wu, Xiangzhao Mao, Fuli Li, Shi’an Wang, Yonghua Wang. Biotechnology in Future Food Lipids: Opportunities and Challenges. Annual Review of Food Science and Technology, 2023, 14:225-246.

9. Ruilin Huang^#, Ruirui Ding^#, Yu Liu, Fuli Li, Zhaohui Zhang^*, Shi’an Wang^*. GATA transcription factor WC2 regulates the biosynthesis of astaxanthin in yeast Xanthophyllomyces dendrorhous. Microbial Biotechnology, 2022, 15(10):2578-2593.

10. Jixuan Hong^#, Ziyue Meng^#, Zixi Zhang^#, Hang Su, Yuxuan Fan, Ruilin Huang, Ruirui Ding, Ning Zhang, Fuli Li*, Shi’an Wang*. Comprehensive analysis of CRISPR-Cas9 editing outcomes in yeast Xanthophyllomyces dendrorhous. The CRISPR Journal, 2022, 5(4):558-570.