Publication List

2025年

He XL, Hu MY, Xu Y, Xia FB, Tan Y, Wang YQ, Xiang HL, Wu H, Ji TF, Xu Q, Wang L, Huang ZH, Sun ML, Wan Y, Cui P, Liang SC, Pan Y, Xiao SY, He Y, Song RX, Yan JQ, Quan X, Wei YG, Hong CZ, Liao WZ, Li FL, El-Omar E, Chen JJ, Qi XL, Gao J, Zhou HW. 2025. The gut-cirrhosis-brain axis for Ruminococcus gnavus-induced neurotoxicity.Nature Medicine, 31:628-638. DOI: 10.1038/s41591-024-03405-9.

Fan SX, Qin MM, Wang Q, Jiang YP, Cong ZQ*. 2025. Semirationally Engineering an Efficient P450 Peroxygenase for Regio- and Enantioselective Hydroxylation of Steroids. ACS Catal, 15(4):2977−2986. DOI: 10.1021/acscatal.4c06342.

Zhang JZ, Li YZ, Xi ZN, Zhang Y, Liu ZY, Ma XQ*, Li FL*. 2025. Inducible promoters of bacterial microcompartments improve the CRISPR/Cas9 tools for efficient metabolic engineering of Clostridium ljungdahlii. Appl Environ Microbiol, 91(4):e02183-24. DOI: 10.1128/aem.02183-24.

Wang QJ, Qin MM, Wang Q, Wang KM, Cong ZQ. 2025. Rationally engineering an H2O2-dependent P450 dihydroxylase for steroid functionalisation. Catal Sci Technol. DOI: 10.1039/D5CY00504C.

Feng MY, Chen ZC, Sun HL, Yao S, Liu ZY, Lv M, Li FL, Wang HZ, Liu LC. 2025. Promoting CO2 electroreduction to C2H4 product by promoting water molecules activation on MgO/CuO catalyst. J Energy Chem, 107:582-590. DOI: 10.1016/j.jechem.2025.03.074.

赖铭池，高欣雨，万赛，刘自勇，李福利，杨松，谭扬. 2025. 食一氧化碳梭菌双功能醛醇脱氢酶的功能研究. 中国生物工程杂志, 45(6):16-27. DOI: 10.13523/j.cb.202501037.

苏娟娟, 郑家文, 苗润泽, 韩鹏, 王士安*, 李福利*. 2025. 微生物油脂与植物油脂的合成生物制造. 合成生物学. DOI: 10.12211/2096-8280.2024-093.

李煜真，贺铭敬，王皓明，马小清，刘立成，李福利*. 2025. 以CO2为原料的第三代生物炼制现状. 化工进展, 44(5):2811-2824. DOI：10.16085/j.issn.1000-6613.2024-1982.

Liu ZR, Wen ZQ, Wu JW, Gao HP, Zhang Q, Li LP, Liu LC, Li Q, Li FL, Liu ZY*. 2025. pH-dependent metabolic regulation in Clostridium ljungdahlii during CO fermentation. Fermentation, 11(3):154. DOI: 10.3390/FERMENTATION11030154.

王士安. 2025.3. 功能营养品类脂肪酸的微生物合成. 工业合成生物学(合成生物学丛书).江会锋、马延和主编. 北京:科学出版社; 济南:山东科学技术出版社,  ISBN 978-7-03-081060-1.

2024年

Poehlein A, Zeldes B, Flaiz M, Böer T, Lüschen A, Höfele F, Baur K S, Molitor B, Kröly C, Wang M, Zhang Q, Fan Y, Chao W, Daniel R, Li F, Basen M, Müller V, Angenent L T, Sousa D Z and Bengelsdorf F R. 2024. Advanced aspects of acetogens. Bioresource Technology, 427:131913. DOI:10.1016/j.biortech.2024.131913.

Jiang FJ, Wang ZH, Cong ZQ. 2024. Tuning the peroxidase activity of artificial P450 peroxygenase by engineering redox-sensitive residues. Faraday Discussions, 252(0):52-68. DOI: 10.1039/d4fd00008k.

Zhang FR, Fan Y, Phung NV, Ji BY, Chen JM, Xu XY, Li FL*, Ji PF*, Yang HJ*, Li XY*. 2024. Nervonic acid alleviates stroke and its associated poststroke depression behaviors. hLife, 2(11):592-606. DOI:10.1016/j.hlife.2024.08.001.

Zhang JZ, Li YZ, Xi ZN, Gao HP, Zhang Q, Liu LC, Li FL, Ma XQ*. 2024. Engineered acetogenic bacteria as microbial cell factory for diversified biochemicals. Front Bioeng Biotechnol, 12:1395540. DOI: 10.3389/fbioe.2024.1395540.

Zhao PX, Jiang YP, Wang Q, Chen J, Yao FQ, Cong ZQ. 2024. Crucial gating residues govern the enhancement of peroxygenase activity in an engineered cytochrome P450 O-demethylase. Chemical Science, 15(21):8062-8070. DOI: 10.1039/d4sc02418d.

Ma XQ, Wang B, Wei W, Tan FC, Su H, Zhang JZ, Zhao CY, Heng HJ, Feng YQ, Shen W, Yang JB*, Li FL*. 2024. Alginate oligosaccharide assimilation by gut microorganisms and the potential role in gut inflammation alleviation. Appl Environ Microbiol, 90(5):00046-24. DOI: 10.1128/aem.00046-24.

Zhang ZY, Xu M, Fan Y, Zhang LY, Wang H. 2024. Using microalgae to reduce the use of conventional fertilizers in hydroponics and soil-based cultivation. Science of The Total Environment, 912: 169424. DOI:10.1016/j.scitotenv.2023.169424.

Ding RR, Huang RL, Su H, Li JW, Li FL, Wang SA. 2024. Screening of astaxanthin-overproducing Xanthophyllomyces dendrorhous strains via iterative ARTP mutagenesis and cell sorting by flow cytometry. J Appl Microbiol, 135(2):lxae020. DOI: 10.1093/jambio/lxae020.

Fan SX and Cong ZQ. 2024. Emerging Strategies for Modifying Cytochrome P450 Monooxygenases into Peroxizymes. Accounts of Chemical Research, 57(4): 613–624. DOI: 10.1021/acs.accounts.3c00746.

Porninta K, Khemacheewakul J, Techapun C, Phimolsiripol Y, Jantanasakulwong K, Sommanee S, Mahakuntha C, Feng J, Htike SL, Kumar A, Moukamnerd C, Zhuang X, Wen W, Wei Q, Li F, Liu T, Nunta R and Leksawasdi N. 2023. Pretreatment and enzymatic hydrolysis optimization of lignocellulosic biomass for ethanol, xylitol, and phenylacetylcarbinol co-production using Candida magnoliae. Front Bioeng Biotechnol, 11: 1332185. DOI: 10.3389/fbioe.2023.1332185.

2023年

Wang HM, Li FL. 2023. The horizontal gene transfer of perchlorate reduction genomic island in three bacteria from an ecological niche. Appl Microbiol Biotechnol, 108(1). DOI:10.1007/s00253-023-12827-3.

Wan S, Lai MC, Gao XY, Zhou MX, Li FL, Xia L, Tan Y. 2023. Recent progress in engineering Clostridium autoethanogenum to synthesize the biochemicals and biocommodities. Synth Syst Biotechnol, 9(1):19-25. DOI: 10.1016/j.synbio.2023.12.001.

Qin X, Jiang Y, Yao F, Chen J, Kong F, Zhao P, Jin L, Cong ZQ. 2023. Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew Chem Int Ed Engl, 62(51):e202311259. DOI: 10.1002/anie.202311259.

Su H, Shi PH, Shen ZS, Meng HM, Meng ZY, Han XF, Chen YN, Fan WM, Fa Y, Yang CY, Li FL*, Wang SA*. 2023. High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by system metabolic engineering. Commun Biol, 6:1125. DOI: 10.1038/s42003-023-05502-w.

Qin XQ, Jiang YP, Chen J, Yao FQ, Jin LY, Cong ZQ. 2023. C(sp3)-H hydroxylation of Broad-Spectrum Alkanes Catalyzed by an Artificial P450 Peroxygenase Driven by ω-Pyridyl Fatty Acyl Amino Acids. Molecular Catalysis, 550:113618. DOI: 10.1016/j.mcat.2023.113618.

Tan Y*, Liang J, Lai MC, Wan S, Luo XZ, Li FL*. 2023. Advances in synthetic biology toolboxes paving the way for mechanistic understanding and strain engineering of gut commensal Bacteroides spp. and Clostridium spp. Biotech Adv, 69:108272. DOI: 10.1016/j.biotechadv.2023.108272.

2023年，一碳生物技术研究中心成立前

Phung NV, Rong F, Xia WY, Fan Y*, Li XY, Wang SA, Li FL*. 2023. Nervonic acid and its sphingolipids: Biological functions and potential food applications. Crit Rev Food Sci Nutr, 64(24):8766-8785. DOI:10.1080/10408398.2023.2203753.

Jiang EY, Fan Y*, Phung NV, Xian WY, Hu GR, Li FL*. 2023. Overexpression of plastid-lipid-associated protein in marine diatom enhances the xanthophyll synthesis and storage. Front Microbiol, 14:1143017. DOI: 10.3389/fmicb.2023.1143017.

Xu QQ, Tang QY, Xu Y, Wu JJ, Mao XZ, Li FL, Wang SA, Wang YH. 2023. Biotechnology in future food lipids: opportunities and challenges. Annu Rev Food Sci Technol, 14:1-22. DOI: 10.1146/annurev-food-060721-024353.

Wang XL, Lin X, Jiang Y, Qin X, Ma N, Yao F, Dong S, Liu C, Feng Y, Jin L, Xian M, Cong ZQ. 2023. Engineering Cytochrome P450BM3 Enzymes for Direct Nitration of Unsaturated Hydrocarbons. Angew Chem Int Ed Engl, 62(13):e202217678. DOI: 10.1002/anie.202217678. 

Zhao PX, Kong F, Jiang Y, Qin X, Tian X, Cong ZQ. 2023. Enabling Peroxygenase Activity in Cytochrome P450 Monooxygenases by Engineering Hydrogen Peroxide Tunnels. J Am Chem Soc, 145(9):5506-5511. DOI: 10.1021/jacs.3c00195.

Chen J, Dong S, Fang W, Jiang Y, Chen Z, Qin X, Wang C, Zhou H, Jin L, Feng Y*, Wang B*, Cong ZQ*. 2023. Regiodivergent and enantioselective hydroxylation of C-H bonds by synergistic use of protein engineering and exogenous dual-functional small molecules. Angew Chem Int Ed Engl, 62: e202215088. DOI: 10.1002/anie.202215088.

2022年

Zhu YX, Zhou W, Dong ZC, Zhang XX, Chen ZP, Liu ZY, Li FL, Fan JX, Jiao MY, Liu LC. 2022. Nanosized LaInO3 perovskite for efficient electrocatalytic reduction of CO2 to formate. Journal of CO2 Utilization, 58:102342. DOI:10.1016/j.jcou.2022.102342.

Zhang XX, Zhu YX, Liu ZY, Li FL, Zhou W, Dong ZC, Fan JX, Liu LC, Du CH. 2022. Perforated nitrogen-rich graphene-like carbon nanolayers supported Cu-In catalyst for boosting CO2 electroreduction to CO. Journal of Energy Chemistry, 75:383-390. DOI:10.1016/j.jechem.2022.09.003.

张全，文志琼，张霖，樊亚超，李福利. 2022. 长链二元酸发酵菌种创制和工艺研究进展. 生物工程学报, 38(12): 4420-4431. DOI: 10.13345/j.cjb.220133.

Zhang XX, Wang ZH, Chen ZP, Zhu YX, Liu ZY, Li FL, Zhou W, Dong ZC, Fan JX, Liu LC*. 2022. Molecular trapdoor mechanism of In-SSZ-13(MP) holds promise for selective electrochemical reduction of CO2 at low concentrations. Applied Catalysis B: Environmental, 317:121771. DOI:10.1016/j.apcatb.2022.121771.

Huang RL, Ding RR, Liu Y, Li FL, Zhang ZH, Wang SA. 2022. GATA transcription factor WC2 regulates the biosynthesis of astaxanthin in yeast Xanthophyllomyces dendrorhous. Microbial Biotechnology, 15(10):2578-2593. DOI: 10.1111/1751-7915.14115.

Yao XQ, Zhang Q, Fan YX, Xu XY, Liu ZY*. 2022. Butanol-isopropanol fermentation with oxygen-tolerant Clostridium beijerinckii XH29. AMB express, 12(1):57. DOI: 10.1186/s13568-022-01399-6.

Hong JX, Meng ZY, Zhang ZX, Su, Fan YX, Huang RL, Ding RR, Zhang N, Li FL*, Wang SA*. 2022. Comprehensive analysis of CRISPR-Cas9 editing outcomes in yeast Xanthophyllomyces dendrorhous. The CRISPR Journal, 5(4):558-570. DOI:10.1101/2021.08.31.4583.

Kong F, Chen J, Qin X, Liu C, Jiang Y, Ma L, Xu H*, Li S*, Cong ZQ*. 2022. Evolving a P450BM3 peroxygenase for the production of indigoid dyes from indoles. Chem Cat Chem, 14 (24). DOI: 10.1002/cctc.202201151.

Di S, Fan S, Jiang F, Cong ZQ*. 2022. A unique P450 peroxygenase system facilitated by a dual-functional small molecule: Concept, application, and perspective. Antioxidants (Basel), 11: 529. DOI: 10.3390/antiox11030529.

Qin X, Jiang Y, Chen J, Yao F, Zhao P, Jin L, Cong ZQ*. 2022. Co-crystal structure-guided optimization of dual-functional small molecules for improving the peroxygenase activity of cytochrome P450BM3. Int J Mol Sci, 23: 7901. DOI: 10.3390/ijms23147901.

2021年

Lee EY, Li FL, Wang Y, Wangikar PP, Guarnieri MT, Luan GD. 2021. Editorial: Bioconversion and Biorefinery of C1 Compounds. Front Microbiol, 12:778962. DOI:10.3389/fmicb.2021.778962.

Yi JH, Huang HY, Liang JY, Wang RF, Liu ZY, Li FL, Wang SN*. 2021. A Heterodimetric Reduced-ferredoxin-dependent methylenetrahydrofolate Reductase from Syngas-fermenting Clostridium ljungdahlii. Microbiology Spectrum, 9(2): e00958-21. DOI: 10.1128/Spectrum.00958-21.

Fan YX, Zhang JZ, Zhang Q, Ma XQ, Liu ZY, Lu M, Qiao K*, Li FL*. 2021. Chapter one - Biofuel and Chemical Production from Carbon One Industry Flux Gas by Acetogenic Bacteria. Advances in Applied Microbiology, 117:1-34. DOI:10.1016/bs.aambs.2021.07.001.

Ding XT, Fan Y, Jiang EY, Shi XY, Krautter E, Hu GR, Li FL*. 2021. Expression of the Vitreoscilla hemoglobin gene in Nannochloropsis oceanica regulates intracellular oxygen balance under high-light. J Photochem Photobiol B: Biol, 221:112237. DOI:10.1016/j.jphotobiol.2021.112237.

Wang B, Dong S, Li FL, Ma XQ*. 2021. Structural basis for the exolytic activity of polysaccharide lyase family 6 alginate lyase BcAlyPL6 from human gut microbe Bacterioides clarus. Biochem Biophy Res Commu, 547:111-117. DOI:10.1016/j.bbrc.2021.02.040.

Wang HH, Li X, Li XY*, LI FL, Su ZC, Zhang HW. 2021. Community composition and co-occurrence patterns of diazotrophs along a soil profile in paddy fields of three soil types in China. Microb Ecol, 82(4):961-970. DOI:10.1007/s00248-021-01716-9.

Li JX, Xu J, Ruan JC, Meng HM, Su H, Han XF, Lv M, Li FL, Wang SA*. 2021. Disrupting a phospholipase A2 gene increasing lipid accumulation in the oleaginous yeast Yarrowia lipolytica. J Appl Microbiol, 130(1):100-108. DOI:10.1111/jam.14779.

Mahor D, Cong Z, Weissenborn MJ, Hollmann F; Zhang W*. 2021. Valorization of small alkanes by biocatalytic oxyfunctionalization. Chem Sus Chem, 14: 1-12. DOI: 10.1002/cssc.202101116.

Zhang X, Jiang Y, Chen Q, Dong S, Feng Y, Cong Z*, Shaik S, Wang B*. 2021. H-bonding networks dictate the molecular mechanism of H2O2 activation by P450. ACS Catal, 11: 8774-8785. DOI:10.1021/acscatal.1c02068.

Zhao PX, Chen J, Ma N, Chen J, Qin X, Liu C, Yao F, Yao L, Jin L, Cong ZQ*. 2021. Enabling highly (R)-enantioselective epoxidation of styrene by engineering unique non-natural P450 peroxygenases. Chem Sci, 12: 6307-6314. DOI: 10.1039/d1sc00317h.