Publication List

2024年

Ma XQ#, Wang B#, Wei W#, Tan FC; Su H, Zhang JZ, Zhao CY, Hua-Jun Zheng HJ, Feng YQ, Shen W, Yang JB*, Li FL*. (2024) Alginate oligosaccharide assimilation by gut microorganisms and the potential role in gut inflammation alleviation. Applied and Environmental Microbiology. 90(5): e0004624.

Wang SA, Su JJ. (2024) Organisms for biofuel production. 10 Breakthrough Ideas in Energy for The Next Ten Years (5th Anniversary edition) ,18-26.

Ding RR, Huang RL, Su H, Li JW, Li FL, Wang SA. (2024) Screening of astaxanthin-overproducing Xanthophyllomyces dendrorhous strains via iterative ARTP mutagenesis and cell sorting by flow cytometry. Journal of Applied Microbiology ,135, lxae020. DOI: https://doi.org/10.1093/jambio/lxae020

Lu M, Lindman B, Holmberg K. (2024) Effect of polymer addition on the phase behavior of oil-water-surfactant systems of Winsor III type. Phys Chem Chem Phys, 26: 3699-3710.

Wang HM, Li FL. (2024) The horizontal gene transfer of perchlorate reduction genomic island in three bacteria from an ecological niche. Appl Microbiol Biotechnol, 108: 22.

Zhang Z, Xu M, Fan Y, Zhang L, Wang H. (2024) Using microalgae to reduce the use of conventional fertilizers in hydroponics and soil-based cultivation. Science of The Total Environment, 912:169424. DOI: 10.1016/j.scitotenv.2023.169424.

2023年，一碳生物技术研究中心成立后

Wang X, Lin X, Jiang Y, Qin X, Ma N, Yao F, Dong S, Liu C, Feng Y, Jin L, Xian M, Cong Z. (2023) Engineering cytochrome P450BM3 enzymes for direct nitration of unsaturated hydrocarbons. Angew Chem Int Ed Engl, 62(13): e202217678. DOI: 10.1002/anie.202217678.

Wan S, Lai M, Gao X, Zhou M, Yang S, Li Q, Li, F, Xia, L, Tan Y. (2023) Recent progress in engineering Clostridium autoethanogenum to synthesize the biochemicals and biocommodities. Synth Syst Biotechnol, 9(1): 19-25.

Qin X, Jiang Y, Yao F, Chen J, Kong F, Zhao P, Jin L, Cong Z. (2023) Anchoring a structurally editable proximal cofactor-like module to construct an artificial dual-center peroxygenase. Angew Chem Int Ed Engl, 62(51): e202311259. DOI: 10.1002/anie.202311259. 

Zhao P, Kong F, Jiang Y, Qin X, Tian X, Cong Z. Enabling peroxygenase activity in cytochrome P450 monooxygenases by engineering hydrogen peroxide tunnels. J Am Chem Soc, 145(9): 5506-5511. DOI: 10.1021/jacs.3c00195.

Qin X, Jiang Y, Chen J, Yao F, Jin L, Cong Z, C(sp3)-H hydroxylation of broad-spectrum alkanes catalyzed by an artificial P450 peroxygenase driven by ω-pyridyl fatty acyl amino acids. (2023) Mol Catal, 550: 113618. DOI: 10.1016/j.mcat.2023.113618.

Zhang H, Wan W, Cui Q, Song X. Modular metabolic engineering of mortierella alpina by the 2A peptide platform to improve arachidonic acid production. J Agric Food Chem, 2023 Aug 23;71(33):12519-12527. DOI: 10.1021/acs.jafc.3c03016. Epub 2023 Aug 10. PMID: 37561084.

Zhang H, Wang Z, Sun C, Zhang C, Liu H, Cui Q, Song X, Wang S. (2023) A phospholipid:diacylglycerol acyltransferase is involved in the regulation of phospholipids homeostasis in oleaginous Aurantiochytrium sp. Biotechnol Biofuels Bioprod, 16(1): 142. DOI: 10.1186/s13068-023-02396-y. 

Li FL, Fan YX. (2023) Biofuels production and development in China. IEA Bioenergy T39 Biofuel News. 63:5-16.

Tan Y*, Liang J, Lai MC, Wan S, Luo XZ, Li FL*. (2023) Advances in synthetic biology toolboxes paving the way for mechanistic understanding and strain engineering of gut commensal Bacteroides spp. and Clostridium spp. Biotech Adv, 69: 108272.

文志琼, 李煜真, 张金刚, 王菲菲, 马小清, 李福利. 化能驱动的产乙酸菌转化利用CO2研究进展[J]. 合成生物学, 1-13. DOI: 10.12211/2096-8280.2023-045.

Su H#, Shi PH#, Shen ZS#, Meng HM, Meng ZY, Han XF, Chen YN, Fan WM, Fa Y, Yang CY, Li FL*, Wang SA*. (2023) High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by system metabolic engineering. Commun Biol, 6: 1125. DOI: 10.1038/s42003-023-05502-w.

2023年，一碳生物技术研究中心成立前

分子微生物工程研究组

Phung NV, Rong F, Xia WY, Fan Y*, Li XY, Wang SA, Li FL*. (2023) Nervonic acid and its sphingolipids: Biological functions and potential food applications. Crit Rev Food Sci Nutr. DOI: 10.1080/10408398.2023.2203753.

Jiang EY, Fan Y*, Phung NV, Xian WY, Hu GR, Li FL*. (2023) Overexpression of plastid-lipid-associated protein in marine diatom enhances the xanthophyll synthesis and storage. Front Microbiol, 14: 1143017. DOI: 10.3389/fmicb.2023.1143017.

Tang WZ, Jiang DD, Fan YX, Zhang Q, Liu LC, Li FL, Liu ZY. (2023) Metabolic difference analysis of Clostridium cellulovorans grown on glucose and cellulose. Fermentation, 9: 321. DOI: 10.3390/fermentation9040321.

万赛，王皓明，马小清，谭扬，刘立成，李福利*. (2023) 碳一气体生物转化中的产乙酸菌改造与发酵工艺优化. 生物工程学报 39 DOI: 10.13345/j.cjb.221004.

Hamouda HI, Fan YX, Abdalla M, Su H, Lu M*, Li FL*. (2023) Distinct roles of carbohydrate-binding modules in multidomain β‑1,3–1,4‑glucanase on polysaccharide degradation. Appl Microbiol Biotechnol, 107: 1751-1764. DOI: 10.1007/s00253-023-12416-4.

Xu QQ, Tang QY, Xu Y, Wu JJ, Mao XZ, Li FL, Wang SA, Wang YH. (2023) Biotechnology in future food lipids: opportunities and challenges. Annu Rev Food Sci Technol. 14: 14.1-14.22. DOI: 10.1146/annurev-food-060721-024353.

单碳酶催化研究组

Chen J#, Dong S#, Fang W#, Jiang Y, Chen Z, Qin X, Wang C, Zhou H, Jin L, Feng Y*, Wang B*, Cong Z*. (2023) Regiodivergent and enantioselective hydroxylation of C-H bonds by synergistic use of protein engineering and exogenous dual-functional small molecules. Angew Chem Int Ed Engl, 62: e202215088. DOI: 10.1002/anie.202215088.

2022年

分子微生物工程研究组

Zhu YX, Zhou W, Dong ZC, Zhang XX, Chen ZP, Liu ZY, Li FL, Fan JX, Jiao MY, Liu LC. (2022) Nanosized LaInO3 perovskite for efficient electrocatalytic reduction of CO2 to formate. J CO2 Util. 58: 102342. DOI: 10.1016/j.jcou.2022.102342.

Zhang XX, Zhu YX, Liu ZY, Li FL, Zhou W, Dong ZC, Fan JX, Liu LC, Du CH. (2022) Perforated nitrogen-rich graphene-like carbon nanolayers supported Cu-In catalyst for boosting CO2 electroreduction to CO. J Energy Chem, 75:383-390. DOI: 10.1016/j.jechem.2022.09.003.

张全，文志琼，张霖，樊亚超，李福利. (2022) 长链二元酸发酵菌种创制和工艺研究进展. 生物工程学报, 38(12): 4420-4431. DOI: 10.13345/j.cjb.220133.

Zhang XX, Wang ZH, Chen ZP, Zhu YX, Liu ZY, Li FL, Zhou W, Dong ZC, Fan JX, Liu LC*. (2022) Molecular trapdoor mechanism of In-SSZ-13(MP) holds promise for selective electrochemical reduction of CO2 at low concentrations. Appl Catal B-Environ, 317: 121771. DOI: 10.1016/j.apcatb.2022.121771.

Huang RL, Ding RR, Liu Y, Li FL, Zhang ZH, Wang SA. (2022) GATA transcription factor WC2 regulates the biosynthesis of astaxanthin in yeast Xanthophyllomyces dendrorhous. Microbial Biotechnology, 15(10): 2578-2593. doi: 10.1111/1751-7915.14115.

Yao XQ, Zhang Q, Fan YX, Xu XY, Liu ZY*. 2022. Butanol-isopropanol fermentation with oxygen-tolerant Clostridium beijerinckii XH29. AMB express, 12(1): 57. doi: 10.1186/s13568-022-01399-6.

师晓艺, 丁晓婷, 万子璇, 英瑜, 李福利*, 高昕*, 范勇. (2022) 产神经酸微藻 Mychonastes afer 的兼养固碳培养. 南方水产科学, 18(2): 134-141. doi: 10.12131/20210307

张俊哲, 张全, 刘自勇, 马小清, 刘立成, 李福利*. (2022) 细菌微室及其在合成生物学中的应用. 南京工业大学学报 44(5):490-499.

Hong JX, Meng ZY, Zhang ZX, Su, Fan YX, Huang RL, Ding RR, Zhang N, Li FL*, and Wang SA*. (2022) Comprehensive analysis of CRISPR-Cas9 editing outcomes in yeast Xanthophyllomyces dendrorhous. The CRISPR Journal, 5(4): 558-570. DOI: 10.1101/2021.08.31.4583.

单碳酶催化研究组

Kong F, Chen J, Qin X, Liu C, Jiang Y, Ma L, Xu H*, Li S*, Cong Z*. (2022) Evolving a P450BM3 peroxygenase for the production of indigoid dyes from indoles. Chem Cat Chem, 14 (24). DOI: 10.1002/cctc.202201151.

Di S, Fan S, Jiang F, Cong Z*. (2022) A unique P450 peroxygenase system facilitated by a dual-functional small molecule: Concept, application, and perspective. Antioxidants (Basel), 11: 529.

Qin X#, Jiang Y#, Chen J, Yao F, Zhao P, Jin L, Cong Z*. (2022) Co-crystal structure-guided optimization of dual-functional small molecules for improving the peroxygenase activity of cytochrome P450BM3. Int J Mol Sci, 23: 7901.

2021年

分子微生物工程研究组

Han X, Lu M*, Fan YX, Li YX, Holmberg K*. 2021. Recent developments on surfactants for enhanced oil recovery. Teside Surf Det, 58(3): 164-176.

杨汇照, 范奕萱, 蒋丹丹, Armin Ehrenreich, 刘晓环, 李福利, 刘自勇. 2021. 丙酮丁醇梭菌硫氧还蛋白系统在溶剂生产过程中的功能. 微生物学报. Doi: 10.13342/j.cnki.wsxb.20210344.

Yi JH, Huang HY, Liang JY, Wang RF, Liu ZY, Li FL, Wang SN*. 2021. A heterodimetric reduced-ferredoxin-dependent methylenetrahydrofolate reductase from syngas-fermenting Clostridium ljungdahlii. Microbiol Spectr, 9(2): e00958-21.

Lee EY, Li FL, Wang Y, Wangikar PP, Guarnieri MT, Luan GD. 2021. Editorial: Bioconversion and biorefinery of C1 compounds. Front Microbiol, 12: 778962. DOI: 10.3389/fmicb.2021.778962.

杨英杰, 马小清, 李福利, 倪金凤*. (2021). 白蚁肠道优势厌氧菌的分离与培养. Bio-101: e2003640. DOI: 10.21769/BioProtoc.2003640.

Ding XT#, Fan Y#, Jiang EY, Shi XY, Krautter E, Hu GR, Li FL*. (2021) Expression of the Vitreoscilla hemoglobin gene in Nannochloropsis oceanica regulates intracellular oxygen balance under high-light. J Photochem Photobiol, B: Biol, 221: 112237. DOI: 10.1016/j.jphotobiol.2021.112237.

Fan Y#, Ding XT#, Wang LJ, Jiang EY, Van PN, Li FL*. (2021) Rapid sorting of fucoxanthin-producing Phaeodactylum triconutum mutants by flow cytometry. Mar Drugs, 19: 228. DOI: 10.3390/md19040228.

Wang B, Dong S, Li FL, Ma XQ*. (2021) Structural basis for the exolytic activity of polysaccharide lyase family 6 alginate lyase BcAlyPL6 from human gut microbe Bacterioides clarus. Biochem Biophy Res Commu, 547: 111-117. DOI: 10.1016/j.bbrc.2021.02.040.

Wang HH, Li X, Li XY*, LI FL, Su ZC, Zhang HW. (2021) Community composition and co-occurrence patterns of diazotrophs along a soil profile in paddy fields of three soil types in China. Microb Ecol, 82(4): 961-970. DOI: 10.1007/s00248-021-01716-9.

Li JX, Xu J, Ruan JC, Meng HM, Su H, Han XF, Lv M, Li FL, Wang SA*. 2021. Disrupting a phospholipase A2 gene increasing lipid accumulation in the oleaginous yeast Yarrowia lipolytica. J Appl Microbiol, 130(1): 100-108. DOI: 10.1111/jam.14779.

王瑞，刘自勇，王琪，彭翠娜，陈中合，李福利，王晓龙，杨成*. (2021) CO2 辅助好氧菌煤炭脱硫工艺的实验研究. 化工进展, 40(1): 533-540. DOI: 10.16085/j.issn.1000-6613.2020-0416.

单碳酶催化研究组

Mahor D, Cong Z, Weissenborn MJ, Hollmann F; Zhang W*. (2021) Valorization of small alkanes by biocatalytic oxyfunctionalization. Chem Sus Chem, 14: 1-12.

Zhang X#, Jiang Y#, Chen Q#, Dong S, Feng Y, Cong Z*, Shaik S, Wang B*. (2021) H-bonding networks dictate the molecular mechanism of H2O2 activation by P450. ACS Catal, 11: 8774-8785.

Ma N#, Fang W#, Liu C, Qin X, Wang X, Jin L, Wang B*, Cong Z*. (2021) Switching an artificial P450 peroxygenase into peroxidase via mechanism-guided protein engineering. ACS Catal. 11: 8449-8455. (Featured in: Kim H, Faculty Opinions 2021, doi: 10.3410/f.740620167.793587804)

Zhao P#, Chen J#, Ma N, Chen J, Qin X, Liu C, Yao F, Yao L, Jin L, Cong, Z*. (2021) Enabling highly (R)-enantioselective epoxidation of styrene by engineering unique non-natural P450 peroxygenases. Chem Sci, 12: 6307-6314. (Back Cover; Featured in: "Hot off the Press" in Nat. Prod. Rep. 2021, 38, 1053)

2020年

分子微生物工程研究组

张全, 查孝胜, 高慧鹏, 李澜鹏*, 关浩, 刘自勇, 乔凯, 李福利*. (2020) 燃料丁醇研究进展及市场前景分析. 生物加工过程. 18(6): 741-748.

Giwa AS, Ali N*, Ahmad I, Asif M, Guo RB, Lu M*, Li FL*. (2020) Prospects of China's biogas: Fundamentals, challenges and considerations. Energy Rep, 6: 2973-2987. DOI: 10.1016/j.egyr.2020.10.027.

Ali N, Hamouda, HI, Su H, Feng J, Liu ZY, Lu M*, Li FL*. (2020) A two-stage anaerobic bioconversion of corn stover: Impact of pure bacterial pretreatment on methane production. Environ Tech Innovation, 20: 101141. DOI: 10.1016/j.eti.2020.101141.

Hamouda HI, Ali N, Su H, Feng J, Lu M*, Li FL*. (2020) Exploration of two pectate lyases from Caldicellulosiruptor bescii reveals that the CBM66 module has a crucial role in pectic biomass degradation. Appl Environ Microbiol, 86(16): e00787-20. DOI: 10.1128/AEM.00787-20.

Geng HW, Mou ZG, Liu ZY, Li FL, Yang C*. (2020) Biochemcial degradation of chitosan over immoblized cellulase and supported fenton catalysts. Catalysts, 10: 604. DOI:10.3390/catal10060604.

Liu ZY, Jia DC, Zhang KD, Zhu HF, Zhang Q, Jiang WH, Gu Y*, Li FL*. (2020) Ethanol metabolism dynamics in Clostridium ljungdahlii grown on carbon monoxide. Appl Environ Microbiol, 86(14): e00730-20 (doi: 10.1128/AEM.00730-20)

Ali N, Hamouda HI, Su H, Li FL, Lu M.* (2020) Combinations of alkaline hydrogen peroxide and lithium chloride/N,N-dimethylacetamide pretreatments of corn stalk for improved biomethanation. Environ Res, 186:109563. DOI: 10.1016/j.envres.2020.109563.

Li MJ, Liu CQ, Yang JM, Nian R, Xian M*, Li FL*, Zhang HB*. (2020) Common problems associated with the microbial productions of aromatic compounds and corresponding metabolic engineering strategies. Biotech Adv, 41:107548. DOI: 10.1016/j.biotechadv.2020.107548.

Zhu HF, Liu ZY, Zhou X, Yi JH, Lun ZM, Wang SN, Tang WZ*, Li FL*. (2020) Energy conservation and carbon flux distribution during fermentation of CO or H2/CO2 by Clostridium ljungdahlii. Front Microbiol, 11: 416. DOI: 10.3389/fmicb.2020.00416.

Ali N, Zhang Q, Liu ZY, Li FL, Lu M*, Fang XC*. (2020) Emerging technologies for the pretreatment of lignocellulosic materials for bio-based products. Appl Microbiol Biotechnol, 104(2): 455-473. DOI: 10.1007/s00253-019-10158-w.

Hu GR, Fan Y, Zheng YL, Xu F, Zhang L, Li FL*. (2020) Photoprotection capacity of microalgae improved by regulating the antenna size of light-harvesting complexes. J Appl Phycol, 32(2): 1027-1039. DOI: 10.1007/s10811-019-01969-5.

徐荆，刘自勇，朱海峰，高亮亮，张培玉*，李福利*. (2020) 丙酮丁醇梭菌半胱氨酸合成途径中铁氧还蛋白和胱硫醚-γ-裂解酶基因功能探究. 微生物学报 60(3): 570-581. DOI: 0.13343/j.cnki.wsxb.2019020252.

Li MJ, Hou FF, Wu T, Jiang XL, Li FL, Liu HB, Xian M*, Zhang HB*. (2020) Recent advances in natural isoprenoid production using cell factories. Nature Product Report, 37: 80-99. DOI: 10.1039/C9NP00016J.

单碳酶催化研究组

王曦翎; 陈杰; 马娜娜; 丛志奇*. (2020) 细胞色素P450酶催化的烷烃选择性羟化. 化学学报, 78(6): 490-503.

Jiang Y#, Wang C#, Ma N, Chen J, Liu C, Wang F, Xu J*, Cong Z*. (2020) Regioselective aromatic: O-demethylation with an artificial P450BM3 peroxygenase system. Catalysis Science & Technology, 10(5), 1219-1223. (Inside Front Cover)

2019年

分子微生物工程研究组

Ji SQ*, Dix SR, Aziz AA, Sedelnikova SE, Baker PJ, Rafferty JB, Bullough PA, Tzokov SB, Agirre J, Li FL*, Rice DW*. (2019) The molecular basis of endolytic activity of a multidomain alginate lyase from Defluviitalea phaphyphila, a representative of a new lyase family, PL39. JBC 294: 18077-18091. DOI:10.1074/jbc.RA119.010716.

冯杰，Hamouda Hamed I.，Ali Nasir，王雨铭，张培玉*，吕明*. (2019) 嗜热厌氧菌 Caldicellulosiruptor sp.F32 中降解β-1,3-1,4 葡聚糖水解酶的协同性分析及糖基化对F32EG5 热稳定性影响. 微生物学报, 59(11): 2144-2154. DOI: 10.13343/j.cnki.wsxb.20180549.

赵晨，孟慧敏，李家欣，张培玉*，李福利，王士安*. (2020) 解脂耶罗维亚酵母工程菌合成超长链脂肪酸及温度影响. 微生物学通报 47(1): 13-23. DOI: 10.13344/j.microbiol.china.190090.

丁晓婷，王丽娟，范勇，张培玉*，李福利. (2020) 甘露醇兼养三角褐指藻生产多不饱和脂肪酸和岩藻黄质. 生物学杂志, 4: 54-57

李福利*. (2019) 中国合成生物学发展前景可期. 高科技与产业化, 272:32-34

Zhang N, Li JX, Li FL, Wang SA*. (2019) Selectable marker recycling in the nonconventional yeast Xanthophyllomyces dendrorhous by transient expression of Cre on a genetically unstable vector. Appl Microbiol Biotechnol, 103(2): 963-971.

单碳酶催化研究组

Chen J, Kong F, Ma N, Zhao P, Liu C, Wang X, Cong Z*. (2019) Peroxide-driven hydroxylation of small alkanes catalyzed by an artificial P450BM3 peroxygenase system. ACS Catal, 9, 7350-7355.

Xu J#, Wang C#, Cong Z*. (2019) Strategies for substrate-regulated P450 catalysis: From substrate engineering to co-catalysis. Chem Eur J, 9(25): 6853–6863. (Invited Concept; Frontispiece; Featured in: Review Showcase)

Ariyasu S, Kodama Y, Kasai C, Cong Z, Stanfield JK, Aiba Y, Watanabe Y, Shoji O*. (2019) Development of a high-pressure reactor based on liquid-flow pressurisation to facilitate enzymatic hydroxylation of gaseous alkanes. Chem Cat Chem, 11(19): 4709-4714.