Clostridium Biotechnology Group
The Clostridium Biotechnology Group is committed to constructing efficient Clostridium cell factories and their corresponding fermentation technologies for converting one-carbon gases and lignocellulosic materials into bulk chemicals, such as bioethanol, biolipids, and feed proteins. With this research focus, the group currently possesses leading domestic expertise in Clostridium genetic editing, anaerobic Clostridium fermentation, and gas fermentation processes. Our team has a strong and extensive external communication network, established through long-term collaborations with the Max Planck Institute and Technical University of Munich in Germany, University of Ulm in Germany, and University of Nottingham in the UK. Within China, we have established strategic partnerships with Shandong University, Dalian Petrochemical Research Institute (SINOPEC), and the Science of Plant Physiology and Ecology, Chinese Academy of Sciences, all working together to foster the rapid and improved development of Clostridium biotechnology.
Cross-Project - Research on the Technology of Producing Fuel Ethanol by Synthetic Gas Bioconversion (Dalian Petrochemical Research Institute, SINOPEC) - E2411B0101, 2022/01-2024/12, 1.7 million RMB.
National Natural Science Joint Fund - Key Supported Project, U21B2099, Research on Electrochemical-Microbial Coupling for Mild Conversion of Carbon Dioxide to Ethanol, 2022/01-2025/12, 2.6 million RMB.
Anaerobic Clostridium Gene Editing Platform, Anaerobic Clostridium Fermentation Platform, Synthetic Gas Fermentation Device with Independent Intellectual Property Rights, and Clostridium Product Analysis and Detection Platform
1. Zi-Yong Liu, De-Chen Jia, Kun-Di Zhang, Hai-Feng Zhu, Quan Zhang, Wei-Hong Jiang, Yang Gu, Fu-Li Li*. Ethanol metabolism dynamics in Clostridium ljungdahlii grown on carbon monoxide. Appl Environ Microbiol. 2020, 86(14) :e00730-20, doi:10.1128/AEM.00730-20.1.
2. Zhu HF#, Liu ZY#, Zhao X, Yi JH, Lun ZM, Wang SN, Tang WZ*, Li FL*.2020. Energy conservation and carbon flux distribution during fermentation of CO or H2/CO2 by Clostridium ljungdahlii. Front Microbiol 11. doi: 10.3389/fmicb.2020.00416.